Autoimmunity

At times, individual immune system attacks wrong body cells in such a way that a number of diseases are developed. This is referred as Auto Immune Disorder. This can rise either by misinterpretation or confusion when body cells are attacked wrongly. Commonly prevalent auto immune disorders are lupus, diabetes, multiple sclerosis, rheumatoid arthritis, chrug strass syndrome and thyroiditis. Low level immunity may prevent the individual from disease and are susceptible to infection during various stages of life.

Classification of autoimmune disease

Auto immune diseases are classified in to two major types depending on the physical clinic pathologic disease features.

• Systematic autoimmune diseases: Not tissue or organ specific
• Local autoimmune diseases: Tissue and organ specific like neurological, dermatological, hematological, gastrointestinal and endocrinological.

Features of autoimmune     

• Immune involvement: This is vital as immune system is included in autoimmune disorders and presence of antibodies in the blood stream.
• Non genetic: Most of autoimmune disorders are genetically inherited. Some disorders may rise from abnormal inheritance pattern. Impact of non genetic is less compared to genetic disorders.
• Multiple antibodies: The same organ producing many numbers of antibodies increases chance of infection and uncertainty.
• Non neonatal disease: This occurs when diseases are inherited during the time of pregnancy through placenta or breast feeding.
• Non contagious: Autoimmune diseases cannot be transmitted to other individuals via blood, fluids or through physical contact.

Causative agents

The antibodies that are produced wrongly when body cells are infected or dead can be because of

• Trigger: Triggering agents like viruses, bacteria, parasites, diet, chemicals, medicines, genetics and immune abnormalities
• Progression: Cancers, radiation and genetics
• Conversion: Mitochondrial disorders, thymus abnormalities

Autoimmune disease treatment

Below mentioned treatments can treat autoimmune disease to some extent.

• Monoclonal antibodies production
• Cytokine
• Suppression of improper functioning of immune system
• Anti inflammatory agents like aspirin and steroids
• T Cell vaccination
• Immuno modulatory therapy
• Helminthic therapy
• Co stimulation blocker
• B cell depleting agent
• Dietary manipulation
• Palliative treatment