Structural genomics

In the late 1990s, real potential value of protein folding began to crack like skyrocket launch during mapping and sequencing of human genomes. The number of model organism was used to study the complete genetic sequencing. With the help of genetic code, scientists were able to predict the amino acid sequence of gene. This led the complete genome sequence open for all types of research, especially to study protein structure from an individual organism or from population or comparing varieties of organisms as well.

Structural genomics helps in determination of three dimensional structure of protein and its function in addition. It helps in identification of amino acid sequence to be coded for better understanding of aspects of protein structure either as helical sheets or linearity. It helps in proper determination of biological roles in specific. For instance, formation of alpha helical sheets depicts that DNA is strongly bound to protein. Structural genomics completely deals with the structure of protein and DNA sequence and perhaps its function.

Protein Structure Initiative (PSI)

With the help of structural genomics study, NIGMS developed PSI (Protein Structure Initiative) in the year 2000.Strategies of PSI have two underlying facts.

• In PSI, initially proteins are clustered in to families depending on the amino acid structure and sequence existence.
• Computed programs and algorithms helps in easy prediction of protein structure and related proteins.  

PSI research scientists developed a modern technology reminiscent of robots with most favorable speed and labor intensive technology to determine the molecular and protein structures. Robots can resolve the structures than never before. This Protein structure initiative study provoked the idea of research and development in its associated fields. PSI scientists in cooperation with molecular biologists send their research findings in protein databases so that the users can easily retrieve the informations.