Significance of Mitosis

Chromosomal set of cells are maintained by mitosis cell division cycle. This mitosis helps in proper receiving of genomes from maternal cells to parental cells. The parental cells have identical copies of genomes which are similar in composition and number of chromosomes. However, the process of transcription will stop the mitosis stage. The epigenetic process helps in active entry in to mitosis stage and the genomes get transmitted to daughter cells or offspring. For instance, book marking function of a cell.

Book Marking:

Book marking is a general phenomenon of epigenetics and genetics. It helps in transmission of memory of the cells while expressing protein by a cell during mitosis stage. It is a vital for cell to maintain their phenotype. For instance, liver cells should be  liver cells after transmission and not forming other such cells. Book marking is mostly characterized by gene promoters during mitotic cell division. Promoter genes found in transcription are marked some way just before cell starts entering in to mitotic stage. This marking is prevalent both in the start or at the end of mitotic stage. This marking aids in transfer of genes thereby preventing DNA compaction during mitotic cell division at loci of DNA. The marking continues by active reassembling of existing transcription complex found on the promoter gene. In most of the cases, book marking occurs before the onset of mitotic cell division cycle. However, in certain cases, it is mediated by the formation of histone. Histone is sustained throughout the mitotic stage.

For instance, hsp70 is the stress inducing gene. Book marking ensures genes  transcribed in G1 phase of cell division cycle when stress occurs. Gene promoter gets compacted and the time for de compaction increases in G1 phase. As a result, the cell is not able to transcribe the cryoprotective gene which leads to death of cell due to stress. Book marking plays an important role in survival of cell.

Mitotic errors are rarely found. If it is prone to erro, then offspring future lies in question. A mitotic error creates distressing results like abnormalities by specific non- disjunction of chromosomes ranging from formation of cancerous cells to death of an individual.